Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. Descriptor: 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide, APOLIPOPROTEIN(A), CHLORIDE ION Authors: Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. Deposit date: 2013-06-25 Release date: 2014-07-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published

靶向载脂蛋白(a)（apolipoprotein(a), apo(a)）kringle结构域KIV-7、KIV-10与KV的选择性小分子抑制剂的鉴定
描述项：5-氯-2-氟-N-[1-(4-哌啶基)吡唑-4-基]苯磺酰胺、载脂蛋白(a)、氯离子
作者：Sandmark, J、Althage, M、Andersson, G.M.K、Antonsson, T、Blaho, S、Bodin, C、Bostrom, J、Chen, Y、Dahlen, A、Eriksson, P.O、Evertsson, E、Fex, T、Fjellstrom, O、Gustafsson, D、Hallberg, C、Hicks, R、Jarkvist, E、Johansson, C、Kalies, I、Kang, D、Svalstedt Karlsson, B、Kartberg, F、Legnehed, A、Lindqvist, A.M、Martinsson, S.A、Moberg, A、Petersson, A.U、Ridderstrom, M、Thelin, A、Tigerstrom, A、Vinblad, J、Xu, B、Knecht, W
提交日期：2013-06-25
发布日期：2014-07-16
最后更新：2024-10-23
实验方法：X射线衍射（分辨率1.68埃）
引用文献：《用于解析载脂蛋白(a) kringle结构域KIV-7、-10及KV病理生理作用的小分子化合物》（待发表）