Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer

RATIONALE: Hepatic arterial infusion uses a catheter to deliver anticancer substances directly into the liver. Drugs used in chemotherapy, such as melphalan, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving an hepatic arterial infusion of melphalan together with hepatic perfusion works in treating patients with unresectable liver cancer.

研究依据：肝动脉输注（hepatic arterial infusion）系通过导管将抗癌物质直接递送至肝脏内。化疗所用药物如美法仑（melphalan），可通过多种机制阻止肿瘤细胞分裂，使其增殖停滞或死亡。采用不同给药方式或可杀灭更多肿瘤细胞。
试验目的：本II期临床试验（phase II trial）旨在评估美法仑肝动脉输注联合肝灌注（hepatic perfusion）治疗不可切除性肝癌（unresectable liver cancer）患者的临床疗效。