Asymmetry by Electrophilic Rearrangement of Symmetric 2-Pyridone Photodimers

Halogenation of achiral trans-2-pyridone photodimers results in 1,3-migration of an amide nitrogen and formation of a chiral structure with six
stereogenic centers and well-differentiated functionality. The reactivity of this product toward nucleophiles, including the allylic halide, is
dominated by participation by the amide nitrogen.

非手性反式-2-吡啶酮（trans-2-pyridone）光二聚体的卤化反应可诱导酰胺氮发生1,3-迁移，并生成含有六个手性中心且官能团分化清晰的手性结构。该产物针对包括烯丙基卤化物在内的亲核试剂的反应活性，主要由酰胺氮的邻基参与作用主导。