A Genome-Wide Association Study of Schizophrenia. Homo sapiens

This study is part of the Molecular Genetics of Schizophrenia (MGS) genome wide association study (GWAS) of 3,972 cases (2,686 EA and 1,286 AA) and 3,629 controls (2,656 EA and 973 AA) (analyzed sample remaining after quality control exclusions), comprised of European ancestry (EA) and African American (AA) samples. We genotyped about half of the EA sample and almost all of the AA sample under the auspices of the Genetic Association Information Network (GAIN) with the Affymetrix 6.0 platform at the Broad Institute. The remainder of the included sample was also genotyped with the Affymetrix 6.0 platform at the Broad Institute, and we refer to this component as the nonGAIN sample. Cases met criteria for schizophrenia (SCZ) or schizoaffective disorder (SA) per the Diagnostic and Statistical Manual of Mental Disorders version IV (DSM-IV) for all three collections (SGI, MGS1, and MGS2) comprising these cases. However, for the older SGI collection, codes for... (for more see dbGaP study page.)

本研究隶属于精神分裂症分子遗传学（Molecular Genetics of Schizophrenia, MGS）全基因组关联研究（Genome Wide Association Study, GWAS）项目，共纳入经质量控制筛选后的3972例病例与3629例对照：其中病例组包含2686例欧洲血统（EA）个体、1286例非裔美国人（AA）个体，对照组包含2656例欧洲血统个体、973例非裔美国人个体，本研究队列涵盖欧洲血统与非裔美国人两类人群。在遗传关联信息网络（Genetic Association Information Network, GAIN）的支持下，我们于博德研究所（Broad Institute）使用Affymetrix 6.0芯片平台对约半数欧洲血统样本与几乎全部非裔美国人样本进行了基因分型。其余纳入样本同样于博德研究所使用Affymetrix 6.0芯片平台完成基因分型，我们将该部分样本称为非GAIN样本。所有病例均符合《精神障碍诊断与统计手册第四版》（Diagnostic and Statistical Manual of Mental Disorders version IV, DSM-IV）中精神分裂症（SCZ）或分裂情感性障碍（SA）的诊断标准，构成该病例队列的三个独立数据集分别为SGI、MGS1与MGS2。不过针对年代较早的SGI数据集，其相关编码信息详见……（更多详情请参阅dbGaP（Database of Genotypes and Phenotypes）研究页面）。