Superenhancer-driven lncRNA FASRL in hepatocellular carcinoma [RNA-seq]. Superenhancer-driven lncRNA FASRL in hepatocellular carcinoma [RNA-seq]

Superenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer-associated lncRNA and abnormal metabolism is unknown. Overall design: In this work, we aimed to investigate the specific mechanism by which superenhancer-related lncRNAs function in lipid metabolism in hepatocellular carcinoma.

超级增强子（Superenhancers）可驱动肿瘤内异常基因表达，并促进肿瘤恶性进展。然而，目前尚不明确超级增强子关联的长链非编码RNA（lncRNA）与异常代谢之间的关联。
实验设计：本研究旨在探究超级增强子相关长链非编码RNA在肝细胞癌脂质代谢中发挥功能的具体分子机制。