RawData_D'Angelo_et_al : The capsule increases susceptibility to last-resort polymyxins, but not to other antibiotics, in Klebsiella pneumoniae

Dataset for manuscript D'Angelo et al <br> The extracellular capsule is a virulence factor present in many facultative pathogens, whose role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four strains of <em>Klebsiella pneumoniae</em> species complex. Non-capsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured by MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation.

D'Angelo等人研究论文配套数据集。胞外荚膜是众多兼性病原菌携带的毒力因子，其在抗菌药物耐药性形成中的作用仍存在争议。为阐明这一学术争议，我们针对肺炎克雷伯菌物种复合体（Klebsiella pneumoniae species complex）的4株菌株开展了6种抗生素的药敏测试。经最低抑菌浓度（Minimum Inhibitory Concentration, MIC）检测，无荚膜菌株对多粘菌素类药物的耐受性显著提升，但对其余抗生素未表现出该现象。本研究结果警示，靶向荚膜的治疗药物可能会筛选出荚膜失活的菌株，临床使用此类药物需谨慎。