Probiotics in the treatment of chronic kidney disease: a systematic review

ABSTRACT Chronic kidney disease (CKD) is a syndrome caused by the progressive reduction of renal function. This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included articles reported positive effects in renal function and decreased levels of urea, blood urea nitrogen, ammonia, plasma p-cresol, p-cresyl sulfate, and indoxyl sulfate.

摘要：慢性肾脏病（Chronic kidney disease, CKD）是一种因肾功能进行性减退所引发的综合征。本研究旨在系统考察益生菌补充疗法用于慢性肾脏病治疗的效果。研究团队在MEDLINE（PubMed）、SciELO、Cochrane及Clinical Trials数据库中开展文献检索。由两名独立评审员筛选研究并提取相关数据。本次检索纳入2012至2016年间发表的、以英文及葡萄牙语撰写的随机临床试验类文献。在82篇初筛合格的文献中，最终有8篇符合研究纳入标准。纳入研究的样本量介于18至101名慢性肾脏病患者之间。所纳入研究的干预周期为4至24周不等。多数纳入文献均报告称，益生菌补充疗法可改善肾功能，并降低患者体内尿素、血尿素氮、氨、血浆对甲酚、对甲酚硫酸盐及吲哚酚硫酸盐的水平。