Dexamethasone treatment of immortalized and primary cancer associated fibroblasts (CAF). Dexamethasone treatment of immortalized and primary cancer associated fibroblasts (CAF)

Glucocorticoids (GCs) are applied as concomitant medication in the course of ADT and chemotherapeutic treatment. therefore, it is essential to investigate specific effects on elevated stromal GR signaling and subsequently clarify a possible influence on tumor growth and disease progression. Overall design: Differential gene expression analysis of RNA-seq data from immortalized PF179T CAF and primary isolated CAFs upon dex and abi treatment. *** Raw data files are not available for the primary patient samples due to privacy concerns. ***

糖皮质激素（Glucocorticoids, GCs）常作为伴随用药应用于雄激素剥夺治疗（Androgen Deprivation Therapy, ADT）与化疗过程中。因此，探究基质糖皮质激素受体（glucocorticoid receptor, GR）信号通路水平升高的具体效应，并进一步阐明其对肿瘤生长与疾病进展的潜在影响，实为必要之举。整体设计：对永生化PF179T癌症相关成纤维细胞（cancer-associated fibroblasts, CAFs）以及原代分离的癌症相关成纤维细胞（CAFs）经地塞米松（dexamethasone, dex）与阿比特龙（abiraterone, abi）处理后的RNA测序数据开展差异基因表达分析。*** 由于隐私保护相关顾虑，原代患者样本的原始数据文件暂未公开。 ***