Re-analysis of an ultra-deep and quantitative saliva proteome

This is a re-analysis of the saliva metaproteome dataset by Grassl et al. (Grassl et al. 2016 Genome Med, 8(1):44 DOI: 10.1186/s13073-016-0293-0) available on ProteomeXchange PXD003028. The data was used as a case study for a method development study in which we developed metaproteomics based methods for quantifying taxonomic composition of microbiomes (microbial communities). We used the fraction data from the original study for individuals 1 (female1), 3 (female3), 5 (male1), and 7 (male3).

本研究对Grassl等人（Grassl et al. 2016 Genome Med, 8(1):44，DOI: 10.1186/s13073-016-0293-0）发布于ProteomeXchange（蛋白质组交换数据库）PXD003028的唾液宏蛋白质组（saliva metaproteome）数据集开展了重新分析。该数据集被用作本研究方法开发工作的案例样本：我们开发了基于宏蛋白质组学（metaproteomics）的分析方法，用于定量解析微生物组（microbiomes，即微生物群落）的分类学组成。本研究选取了原始研究中个体1（女性1）、个体3（女性3）、个体5（男性1）以及个体7（男性3）的组分数据进行分析。