遇见数据集

Number (#) of potential bioactive peptides (per protein molecule) identified in the intact endogenous and dietary proteins and the A<sub>O</sub><sup>1</sup> and Y<sup>2</sup> values.

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NIAID Data Ecosystem2026-03-08 收录
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1AO is the frequency of occurrence of bioactive fragments in a protein sequence, calculated as where, aO is the total number of identified bioactive peptides present in the protein or the number of bioactive peptides with a specific activity based on the BIOPEP database [22], N is the total number of amino acid residues within the protein. 2Y is the relative frequency of occurrence of bioactive fragments with a specific activity in a protein sequence, calculated as where, Aoj is the number of peptides with a specific activity, l is the total number of peptide sequences across all activity categories present within the protein, j is the specified activity. 31 antiamnestic, 2 ACE-inhibitor, 3 antithrombotic, 4 stimulating (glucose uptake-, -vasoactive substance release), 5 regulating (ion flow-, stomach mucosal membrane activity-, phosphoinositol mechanism peptide-), 6 antioxidative, 7 bacterial permease ligand, 8 inhibitor (dipeptidyl peptidase IV inhibitor-, dipeptidyl-aminopeptidase IV inhibitor-, dipeptidyl carboxypeptidase-, CaMPDE-, neuropeptide-), 9 hypotensive, 10 activating ubiquitin mediated proteolysis. 4Overall AO represents the total number of amino acid sequences corresponding to known bioactive peptides identified per protein molecule across all bioactivity categories normalised for amino acid chain length. 5The total number of bioactive peptides represents the total number of amino acid sequences corresponding to known bioactive peptides identified per protein molecule across all bioactivity categories (not just the 10 bioactivity categories shown above).

1. AO为蛋白质序列中生物活性片段的出现频率,其计算公式为:其中aO为该蛋白质中已鉴定的生物活性肽总数,或是基于BIOPEP数据库(BIOPEP database)[22]得到的具有特定活性的生物活性肽数量;N为该蛋白质内的氨基酸残基总数量。 2. Y为蛋白质序列中具有特定活性的生物活性片段的相对出现频率,其计算公式为:其中Aoj为具有该特定活性的肽段数量,l为该蛋白质内所有活性类别下的肽段序列总数,j为指定的活性类型。 3. 本次列出的10种生物活性类别依次为:1 抗记忆活性(antiamnestic)、2 血管紧张素转换酶(ACE)抑制活性(ACE-inhibitor)、3 抗血栓活性(antithrombotic)、4 刺激活性(stimulating,涵盖葡萄糖摄取、血管活性物质释放)、5 调节活性(regulating,涵盖离子流动、胃黏膜活性、磷酸肌醇机制肽)、6 抗氧化活性(antioxidative)、7 细菌通透酶配体活性(bacterial permease ligand)、8 抑制活性(inhibitor,涵盖二肽基肽酶IV抑制剂、二肽基氨基肽酶IV抑制剂、二肽基羧肽酶、CaMPDE、神经肽)、9 降压活性(hypotensive)、10 泛素介导的蛋白水解激活活性(activating ubiquitin mediated proteolysis)。 4. 总体AO为每蛋白质分子在所有生物活性类别下鉴定到的、对应已知生物活性肽的氨基酸序列总数,并经氨基酸链长度归一化处理后的值。 5. 生物活性肽总数指每蛋白质分子在所有生物活性类别(而非仅上述10种生物活性类别)下鉴定到的、对应已知生物活性肽的氨基酸序列总数量。

创建时间:
2014-06-05
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