Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes

This is an observational, case-control study evaluating the quantitative level of Septin9 in plasma pre- and post-colectomy in hereditary colorectal cancer (CRC) syndrome patients (Familial Adenomatous Polyposis (FAP), Lynch syndrome (also known as HNPCC), and Multiple Adenomatous Polyposis (MAP, also known as MYK/MYH) cases) and genetically related FAP-family members as controls and references.

本研究为一项观察性病例对照研究，旨在评估两类人群在结直肠切除术前后血浆中的Septin9定量水平：一类为遗传性结直肠癌（CRC）综合征患者，包括家族性腺瘤性息肉病（FAP）、林奇综合征（亦称遗传性非息肉病性结直肠癌HNPCC）以及多发性腺瘤性息肉病（MAP，亦称MYK/MYH型）患者；另一类为作为对照与参照的遗传相关FAP家族成员。