Microbiome of sputum samples from pulnomary tuberculosis patients. Homo sapiens

TB is a worldwide pandemic. India has thehighest burden of TB, with WHO statistics for 2013giving an estimated incidence figure of 2.1 millioncases for India out of a global incidence of 9 million.Microbiota have been shown to be associated withmany disease conditions; however, only few studieshave been reported for microbiota associated with TB infection. For the first time, we characterized the composition of microbiota of TB patients of India, using high-throughput 16S rRNA gene sequencing and compared it with healthy controls.

结核病（Tuberculosis, TB）是一场全球性大流行病。印度的结核病负担居全球首位，根据世界卫生组织（World Health Organization, WHO）2013年的统计数据，全球结核病新发病例达900万例，其中印度估算新发病例为210万例。微生物群（microbiota）已被证实与多种疾病状态相关，但目前针对结核病感染相关微生物群的研究报道仍较为有限。本研究首次采用高通量16S rRNA基因测序技术，对印度结核病患者的微生物群组成进行了特征解析，并与健康对照人群展开对比分析。