DataSheet_1_The Reliability and Validity of the Malay Version of Polycystic Ovarian Syndrome Health-Related Quality of Life Questionnaire.doc

The Polycystic Ovary Syndrome Questionnaire is a reliable instrument for measuring health-related quality of life. This study aimed to develop a Malay version of the Polycystic Ovary Syndrome Questionnaire and to evaluate the health-related impact of Malaysian women with polycystic ovary syndrome. The participants were women who were diagnosed with polycystic ovary syndrome using Rotterdam criteria in a gynecology clinic. Reliability was determined by internal consistency using Cronbach’s coefficient alpha and test–retest reliability using an intra-class correlation coefficient. Validity was assessed through convergent and discriminant validity. Examining the correlation between similar content of the Malay version of the Polycystic Ovary Syndrome Questionnaire and the SF-36 assessed the convergent validity. The discriminant validity was assessed using the known group comparison. Cronbach’s alpha coefficient was over 0.70 for the total scale and over 0.60 for each subscale. Known group comparison supported the discriminant validity. The Malay version of the Polycystic Ovary Syndrome Questionnaire differentiated between the subgroups of women who differed in polycystic ovary syndrome-specific symptoms. Convergent validity was consistent with the good positive correlation between related subscales of the two instruments. Polycystic ovary syndrome women in Malaysia scored the lowest for the weight (3.74) and infertility (3.41) domains, thereby indicating worse health status in these domains. Body hair (5.42) was the least troublesome for the local population. The Malay version of the Polycystic Ovary Syndrome Questionnaire is a reliable and valid tool for assessing the health-related quality of life among women in the local population. It can be used to objectively assess the quality of life among Malaysian women with polycystic ovary syndrome and evaluate their responsiveness to treatment modalities.

多囊卵巢综合征问卷（Polycystic Ovary Syndrome Questionnaire）是一款用于评估健康相关生活质量的可靠工具。本研究旨在编制马来语版多囊卵巢综合征问卷，并评估马来西亚多囊卵巢综合征女性患者的健康相关影响。研究对象为在妇科诊所经鹿特丹标准（Rotterdam criteria）确诊的多囊卵巢综合征女性患者。信度通过内部一致性（采用克朗巴哈α系数（Cronbach’s coefficient alpha））与重测信度（采用组内相关系数（intra-class correlation coefficient））进行评估。效度通过会聚效度与区分效度两类方式测评：通过分析马来语版多囊卵巢综合征问卷与健康调查简表（SF-36）相似维度的相关性评估会聚效度，采用已知组别比较法验证区分效度。结果显示，总量表的克朗巴哈α系数大于0.70，各维度的克朗巴哈α系数均大于0.60；已知组别比较法结果支持该问卷具备区分效度，马来语版多囊卵巢综合征问卷能够区分不同多囊卵巢综合征特异性症状的女性亚组。会聚效度结果与两种工具相关维度间的显著正相关结果一致。马来西亚多囊卵巢综合征女性患者在体重（3.74）与不孕（3.41）维度得分最低，提示该类人群在上述领域的健康状况较差；多毛症状（5.42）为本地区人群最不困扰的问题。综上，马来语版多囊卵巢综合征问卷是一款可靠且有效的工具，可用于评估本地区女性的健康相关生活质量；其可客观评估马来西亚多囊卵巢综合征女性患者的生活质量，并评价其对不同治疗方案的响应性。