Affymetrix SNP array data for acute-type adult T-cell leukemia (ATL) samples

We recently mapped 605 chromosomal breakpoints in 61 ATL cases by spectral karyotyping and identified chromosome 14q11 as one of the most common chromosomal breakpoint regions. To map the precise location of chromosomal breakpoints at 14q11, we performed single-nucleotide polymorphism (SNP)-based comparative genomic hybridization on leukemia cells from acute-type ATL patients. Copy number analysis of Affymetrix 50K SNP arrays was performed for leukemic cell samples from10 acute-type ATL patients.

本研究近期通过光谱核型分析对61例成人T细胞白血病/淋巴瘤（Adult T-cell Leukemia/Lymphoma, ATL）病例中的605个染色体断裂点进行了定位，并鉴定出14q11染色体区域为最常见的染色体断裂点区域之一。为精确定位14q11区域的染色体断裂点，本研究对急性型成人T细胞白血病/淋巴瘤患者的白血病细胞开展了基于单核苷酸多态性（single-nucleotide polymorphism, SNP）的比较基因组杂交实验。此外，本研究针对10例急性型成人T细胞白血病/淋巴瘤患者的白血病细胞样本，完成了Affymetrix 50K SNP芯片的拷贝数分析。