MYH6 gene promoter in isolated ventricular septal defects

This study enrolled 604 subjects. A total of 464 Chinese patients with isolated and sporadic VSD underwent repair surgery from January 2018 to August 2019 at the Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin, China. A total of 311 VSD patients (167 males and 144 females; age range: 1 month to 12 years) were enrolled in this study. The exclusion criteria were patients without blood samples, or with a family history of CHD, or with other comorbid hereditary disorders. The blood samples from those patients were collected. In addition, blood samples from 293 healthy controls (166 males and 127 females; age range: 1 month to 12 years) were also collected.

本研究共纳入604名研究对象。2018年1月至2019年8月，泰达国际心血管病医院（中国天津）心血管外科共收治464例中国籍孤立性、散发性室间隔缺损（Ventricular Septal Defect, VSD）患者并实施修复手术。本研究从上述患者中纳入311例室间隔缺损患者，其中男性167例、女性144例，年龄范围为1个月至12岁。本研究的排除标准为：未留存血液样本者、存在先天性心脏病（Congenital Heart Disease, CHD）家族史者，或合并其他遗传性疾病者。研究人员收集了上述纳入患者的血液样本。此外，本研究同时收集了293名健康对照者的血液样本，其中男性166例、女性127例，年龄范围为1个月至12岁。