Analysis of genome occupancy of Chd8 and H3K4me3 peaks in embryonic stem cells and differentiaing ESCs and associated ATAC-seq profiles in the presence and absence of Chd8. Analysis of genome occupancy of Chd8 and H3K4me3 peaks in embryonic stem cells and differentiaing ESCs and associated ATAC-seq profiles in the presence and absence of Chd8

In this work, we show a role for Chd8 in the regulation of Xist RNA, the master regulator of X chromosome inactivation (XCI) Overall design: ES cells and differentiang ES cells (3 day differentiated cella, Neuronal Progenitor cells (NPCs))

本研究阐明了染色质域解旋酶DNA结合蛋白8（Chd8）在调控X染色体失活（XCI）的核心调控因子Xist RNA中的功能。实验设计：实验样本涵盖胚胎干细胞（ES cells）、分化3天的胚胎干细胞以及神经前体细胞（NPCs）。