Descriptions of immune and inflammation associated gene co-expression modules.

Each module was divided into submodules in which each member gene’s expression was positively or negatively correlated with the module's eigengene (denoted kME+ and kME-, respectively). For each module, we provide the number of transcripts assigned to each submodule, the top DAVID annotation clusters for each submodule (parenthesis shows the-log10 of the average enrichment P value for all annotations in the cluster), the top enriched biological processes determined using ToppCluster (parenthesis shows the-log10 of the FDR-adjusted P value), the enrichment of established transcription factor binding sites in each submodule (TFBS; parenthesis shows the-log10 of the FDR-adjusted P value; performed using ToppCluster), and the enrichment score of a set of IFN-stimulated genes (see Methods; enrichment score is the-log10 of the FDR-adjusted P value).Descriptions of immune and inflammation associated gene co-expression modules.

每个模块均被划分为若干子模块，其中模块内各成员基因的表达水平与该模块的特征基因（module eigengene）呈正相关或负相关，分别记为kME+与kME-。针对每个模块，本数据集提供以下信息：分配至各子模块的转录本数目、每个子模块排名最高的DAVID注释聚类（括号内标注该聚类中所有注释的平均富集P值的-log10转换值）、通过ToppCluster鉴定得到的排名最高的富集生物学过程（括号内标注经错误发现率（False Discovery Rate, FDR）校正后的P值的-log10转换值）、各子模块中已验证转录因子结合位点（TFBS）的富集情况（括号内标注经FDR校正后的P值的-log10转换值，分析由ToppCluster完成），以及一组干扰素刺激基因（IFN-stimulated genes）的富集得分（详见方法部分；富集得分为经FDR校正后的P值的-log10转换值）。本数据集为免疫与炎症相关基因共表达模块的相关描述。