Detection of CTX-M-27 b-lactamases on two distinct plasmid types in ST38 Escherichia coli from several US states, Dec 28 '20

Infections caused by extended-spectrum B-lactamase (ESBL)-producing Escherichia coli are a significant cause of morbidity and healthcare costs. Globally, the prevailing clonal type is ST131. In the United States (US), ST131 is commonly associated with the B-lactamase blaCTX-M-15, whereas blaCTX-M-14 and blaCTX-M-27 are prevalent in other regions. We identified ST38 ESBL-producing E. coli from different regions in the US. This strain is frequently associated with blaCTX-M-27 embedded on two distinct plasmid types, suggesting the potential emergence of new ESBL lineages.

产超广谱β-内酰胺酶（extended-spectrum β-lactamase，ESBL）的大肠埃希菌（Escherichia coli）感染是引发发病与医疗成本升高的重要诱因。全球范围内，主流克隆型为ST131。在美国（US），ST131通常与β-内酰胺酶blaCTX-M-15相关，而blaCTX-M-14与blaCTX-M-27在其他地区更为流行。本研究从美国多个地区分离得到产ESBL的ST38大肠埃希菌。该菌株常与嵌入两种不同质粒型别的blaCTX-M-27相关，提示新型ESBL克隆谱系可能正在出现。