Metastatic testicular Sertoli cell tumor in a free-ranging cryptorchid adult spotted seal Phoca largha in North Slope, Alaska, USA Diseases of Aquatic Organisms

This case describes a metastatic Sertoli cell tumor (SCT) with lymphatic spread to the abdominal and thoracic lymph nodes, pancreas, and adrenal gland in an adult spotted seal Phoca largha. The neoplasm was composed of tubules lined by palisading neoplastic cells separated by a variably dense fibrous stroma. This pinniped was 1 of 2 cryptorchid seals and the sole case of genital neoplasia among 70 ice seals necropsied by the North Slope Borough from 2012 to 2017. Overall, SCTs are rarely reported in marine mammals. Grant no. NA13NMF 4380158 Grant no. NA13NMF4380158

本案例报道了一例发生淋巴转移的塞尔托利细胞瘤（Sertoli cell tumor, SCT），该肿瘤经淋巴道扩散至成年斑海豹（Phoca largha）的胸腹淋巴结、胰腺及肾上腺。该肿瘤由栅栏状排列的瘤细胞构成管状结构，瘤管之间为疏密程度不一的纤维性间质。这只鳍足类动物为2只隐睾海豹中的1只，同时也是2012年至2017年间北坡自治市（North Slope Borough）对70例冰海豹开展尸检工作中，唯一一例发生生殖系统肿瘤的病例。总体而言，海洋哺乳动物中塞尔托利细胞瘤的相关报道极为罕见。本研究资助编号：NA13NMF4380158，NA13NMF4380158