BEN HIV AE Deidentified datasets

For this study, we hypothesized that individuals in the South African population of African descent will have a lower average leucocyte and neutrophil count when compared to a non-African cohort. We also assessed the influence of BEN on the risk for HIV acquisition, as well as its effect on adverse event reporting in a clinical trial.

We analysed data from the double-blind, placebo-controlled randomized trial HVTN 503 and its follow-on study HVTN 503-S to assess the prevalence of BEN, its association with HIV infection, and AE reporting. These data were then compared with a time- and age-matched, non-pregnant cohort from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007-2008 in the United States (US).

The complete NHANES data are publicly available on the following link: https://wwwn.cdc.gov/nchs/nhanes/Search/DataPage.aspx?Component=Questionnaire&CycleBeginYear=2007

HVTN 503 data will be made available on a website link.

本研究提出假设：非洲裔南非人群的平均白细胞计数与中性粒细胞计数均低于非非洲裔队列。本研究同时评估了BEN对HIV感染风险的影响，及其在临床试验中对不良事件报告的作用。

我们对双盲安慰剂对照随机试验HVTN 503及其后续研究HVTN 503-S的数据进行分析，以评估BEN的流行率、其与HIV感染的关联以及不良事件（Adverse Event, AE）报告情况。随后将这些数据与2007-2008年在美国（United States, US）开展的美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）中按时间与年龄匹配的非妊娠队列进行对比。

NHANES完整数据集可通过以下链接公开获取：https://wwwn.cdc.gov/nchs/nhanes/Search/DataPage.aspx?Component=Questionnaire&CycleBeginYear=2007

HVTN 503的相关数据将通过指定网站链接对外发布。