Camellia oleifera Oil alleviate lipid metabolism disorders in high-fat diet-induced mice through modulating the gut microbiota

Camellia oleifera Oil (CO) is a premium woody edible oil. It exhibits the potential to regulate blood lipids, retard atherosclerosis, and protect against cardiovascular and cerebrovascular ailments. However, its precise mechanism of action remains elusive. Our objective was to elucidate the fundamental mechanism by which CO alleviates lipid metabolism disorders.In the treatment of in high-fat diet-induced mice with CO, we found that CO can significantly reduce body weight, serum triglyceride, total cholesterol and low-density lipoprotein cholesterol levels, the accumulation of lipid droplets in the liver. The analyses of transcriptome sequencing, gut microbiota composition, and serum bile acid profiles demonstrated that CO revealed that CO stimulates the activation of Cyp7a1, consequently resulting in increased excretion and reabsorption of bile acids. Additionally, it elevated the abundance of BSH-active bacteria.

油茶籽油（Camellia oleifera Oil, CO）是一种优质木本食用油，具备调节血脂、延缓动脉粥样硬化、预防心脑血管疾病的潜力，但其确切作用机制至今仍未阐明。本研究旨在明确CO缓解脂质代谢紊乱的核心机制。在对高脂饮食诱导的小鼠开展CO干预治疗后，结果显示CO可显著降低小鼠体重、血清甘油三酯、总胆固醇及低密度脂蛋白胆固醇水平，并减少肝脏脂质滴蓄积。通过转录组测序、肠道菌群组成分析与血清胆汁酸谱分析，结果表明CO可激活Cyp7a1，进而促进胆汁酸的排泄与重吸收；此外，CO还可提升胆盐水解酶活性菌（Bile Salt Hydrolase-active bacteria, BSH）的丰度。