High-carbohydrate-induced ROS burst as the primary culprit in MASLD: evidence from carbohydrate-intolerant carnivorous fish Micropterus salmoides

High-carbohydrate diet (HCD) is a significant nutritional factor inducing metabolic dysfunction-associated steatotic liver disease (MASLD). The core mechanism involves metabolic dysregulation and cellular damage triggered by reactive oxygen species (ROS) burst, although the specific molecular mechanisms remain to be elucidated. Modeled on the carnivorous fish Micropterus salmoides, a species with extreme carbohydrate intolerance, this study investigates how ROS burst drives the progression of HCD-induced liver damage.

高碳水化合物饮食（High-carbohydrate diet, HCD）是诱发代谢功能障碍相关脂肪性肝病（metabolic dysfunction-associated steatotic liver disease, MASLD）的关键营养因素。其核心机制涉及活性氧（reactive oxygen species, ROS）爆发引发的代谢紊乱与细胞损伤，但具体分子机制仍有待阐明。本研究以碳水化合物不耐受特征极端显著的肉食性鱼类大口黑鲈（Micropterus salmoides）为模型，探究ROS爆发如何推动高碳水化合物饮食诱导的肝损伤进程。