Suppression of inflammaging prolongs hematopoietic healthspan [dataset 1]. Suppression of inflammaging prolongs hematopoietic healthspan [dataset 1]

The impact of Thbs1 gene deletion on HSC activity in vivo is unexplored. In this experiment, RNA Seq analysis was performed on BM HSCs derived from young (4 month-old) control and Thbs1 knockout mice to characterize transcriptional alterations resulting from constitutive deletion of Thbs1. Overall design: Comparative gene expression profiling analysis of BM HSCs derived from control and Thbs1 knockout mice.

目前关于血小板反应蛋白1（Thrombospondin 1, Thbs1）基因缺失对体内造血干细胞（Hematopoietic Stem Cell, HSC）活性的影响尚未被探索。本实验针对来源于4月龄年轻野生型对照组与Thbs1基因敲除小鼠的骨髓（Bone Marrow, BM）造血干细胞（HSC）开展RNA Seq分析，以阐明Thbs1组成性敲除所引发的转录组变化特征。实验整体设计：对来源于野生型对照组与Thbs1基因敲除小鼠的骨髓造血干细胞进行比较基因表达谱分析。