Genetic Epidemiology of COPD

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and the only leading cause of death that is steadily increasing in frequency. This project will establish a racially diverse cohort that is sufficiently large and appropriately designed for genome-wide association analysis of COPD. A total of 10,000 subjects will be recruited, including control smokers, definite COPD cases (GOLD Stage 2 to 4), and subjects not included in either group (GOLD 1 or GOLD-Unclassified). This cohort will be used for cross-sectional analysis, although long-term longitudinal follow-up will be a future goal. The primary focus of the study will be genome-wide association analysis to identify the genetic risk factors that determine susceptibility for COPD and... (for more see dbGaP study page.)

慢性阻塞性肺疾病（Chronic obstructive pulmonary disease, COPD）是美国第四大致死性疾病，也是唯一一例发病率持续攀升的主要死亡原因。本项目将构建一个种族多元、样本量充足且设计合理的队列，用于开展慢性阻塞性肺疾病的全基因组关联分析。本研究计划招募共计10000名受试者，涵盖对照吸烟者、确诊慢性阻塞性肺疾病病例（GOLD 2至4期）以及未归入上述两组的受试者（GOLD 1期或GOLD未分类病例）。该队列将用于横断面分析，而长期纵向随访则为未来的研究目标。本研究的核心聚焦于全基因组关联分析，以明确决定慢性阻塞性肺疾病易感性的遗传风险因子及……（更多详情请参见dbGaP研究页面）