The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc

The transcriptomic analysis of the BNIP3-deficient cells showed dysregulation of cellular functions including membrane and cytoskeletal integrity, ECM-growth factor signaling, protein quality control with an overall increase in themes related to angiogenesis and innate immune response.针对BNIP3缺陷细胞的转录组分析显示，其细胞功能出现失调，涵盖膜与细胞骨架完整性、细胞外基质-生长因子信号通路及蛋白质质量控制等多个方面，且与血管生成和固有免疫应答相关的主题整体呈现上调趋势。