Genetic polymorphisms of very important pharmacogene variants in the Chinese Lisu population - supplementary material

<strong>Supplementary Figure 1</strong> The genotype frequency distribution of rs20417 (<em>PTGS2</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 2</strong> The genotype frequency distribution of rs776746 (<em>CYP3A5</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 3</strong> The genotype frequency distribution of rs1805123 (<em>KCNH2</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 4</strong> The genotype frequency distribution of rs2115819 (<em>ALOX5</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 5</strong> The genotype frequency distribution of rs4291 (<em>ACE</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 6</strong> The genotype frequency distribution of rs1051298 (<em>SLC19A1</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Figure 7</strong> The genotype frequency distribution of rs1065852 (<em>CYP2D6</em>) among 27 populations. The value of the Y axis represents the genotype frequency (%). 

<strong>Supplementary Table 1 PCR primers for the selected variants</strong>

<strong>Supplementary Table 2 The Genotype Distribution Difference between Lisu and 26 other populations with Bonferroni’s multiple correction</strong>

<strong>Supplementary Table 3 The genotype and allele frequency distribution of seven SNPs among 27 populations</strong>

<strong>Supplementary Table 4 Clinical Annotations of selected SNPs</strong>

<strong>Supplementary Table 5 Significant Difference SNP and Drug Related Information</strong>

<strong>补充图1</strong> rs20417（<em>PTGS2</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图2</strong> rs776746（<em>CYP3A5</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图3</strong> rs1805123（<em>KCNH2</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图4</strong> rs2115819（<em>ALOX5</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图5</strong> rs4291（<em>ACE</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图6</strong> rs1051298（<em>SLC19A1</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充图7</strong> rs1065852（<em>CYP2D6</em>基因）在27个人群中的基因型频率分布。Y轴数值代表基因型频率（%）。

<strong>补充表1</strong> 所选变异位点的PCR引物

<strong>补充表2</strong> 傈僳族与其他26个人群基因型分布差异（经Bonferroni多重校正）

<strong>补充表3</strong> 七个单核苷酸多态性（SNP）在27个人群中的基因型及等位基因频率分布

<strong>补充表4</strong> 所选SNP的临床注释

<strong>补充表5</strong> 显著差异SNP及药物相关信息