Synthesis of Enantiopure P‑Stereogenic Diphosphacrowns using P‑Stereogenic Secondary Phosphines

A new
synthetic route to enantiopure P-stereogenic benzodiphosphacrowns
using a P-stereogenic secondary bisphosphine as the key building block
is reported. Syntheses of the enantiomer and P-stereogenic crowns
with various ring structures, as well as deboranation of the crown
compounds and subsequent reaction with a platinum complex, are described.

本文报道了一种以P手性（P-stereogenic）二级双膦（secondary bisphosphine）为关键构筑单元，制备对映纯（enantiopure）P手性苯并二磷杂冠醚（benzodiphosphacrowns）的全新合成路径。同时，本文系统阐述了具有不同环结构的对映体及P手性冠醚的合成方法、冠醚化合物的脱硼（deboranation）反应，以及其后续与铂配合物（platinum complex）的反应。