Supplementary Material for "Comprehensive Analysis of Disease Pathology in Im-munocompetent and Immunocompromised hosts fol-lowing pulmonary SARS-CoV-2 Infection"

Supplementary Materials: The following figure/tables are uploaded here: Figure S1: Histopathology of the trachea in SARS-CoV-2 infected hamsters. Figure S2: qPCR analysis of B and T cell lineage markers in LD and CP-LD infected hamster lungs Figure S3: Histopathology of the adrenal gland in SARS-CoV-2 infected hamsters Figure S4: White pulp content in the spleen of SARS-CoV-2 infected hamsters. Figure S5: Acute renal tubular necrosis in SARS-CoV-2 infected hamsters. Figure S6: Top canonical pathways operative in immunocompetent hamster lungs infected with low-dose SARS-CoV-2 at 4 days post-infection Figure S7: Top canonical pathways operative in immunocompetent hamster lungs infected with low-dose SARS-CoV-2 at 16 days post-infection Figure S8: Canonical hypercytokinemia/hyperchemokinemia pathway map Figure S9: Canonical interferon signaling pathway map Figure S10: Top canonical pathways operative in immunocompromised hamster lungs infected with low-dose SARS-CoV-2 at 4 days post-infection Figure S11: Top canonical pathways operative in immunocompromised hamster lungs infected with low-dose SARS-CoV-2 at 16 days post-infection Table S1: Differentially regulated biological functions at 4dpi versus uninfected hamster lungs Table S2: Differentially regulated biological functions at 16dpi versus uninfected hamster lungs Table S3: Differentially regulated biological functions in immunosuppressed SARS-CoV-2 infected hamster lungs at 4dpi Table S4: Differentially regulated biological functions in immunosuppressed SARS-CoV-2 infected hamster lungs at 16dpi Table S5: List of primers used for hamster and SARS-CoV-2 genes in the present study

补充材料：本文上传了如下图表：
图S1：新型冠状病毒（SARS-CoV-2）感染仓鼠的气管组织病理学特征
图S2：低剂量（LD）与CP-LD感染仓鼠肺部B细胞和T细胞谱系标志物的定量聚合酶链反应（qPCR）分析
图S3：新型冠状病毒（SARS-CoV-2）感染仓鼠的肾上腺组织病理学特征
图S4：新型冠状病毒（SARS-CoV-2）感染仓鼠的脾脏白髓含量
图S5：新型冠状病毒（SARS-CoV-2）感染仓鼠的急性肾小管坏死
图S6：感染后4天，低剂量新型冠状病毒（SARS-CoV-2）感染的免疫健全仓鼠肺部的核心经典信号通路
图S7：感染后16天，低剂量新型冠状病毒（SARS-CoV-2）感染的免疫健全仓鼠肺部的核心经典信号通路
图S8：经典细胞因子风暴/趋化因子风暴通路图谱
图S9：经典干扰素信号通路图谱
图S10：感染后4天，低剂量新型冠状病毒（SARS-CoV-2）感染的免疫缺陷仓鼠肺部的核心经典信号通路
图S11：感染后16天，低剂量新型冠状病毒（SARS-CoV-2）感染的免疫缺陷仓鼠肺部的核心经典信号通路
表S1：感染后4天（dpi，days post-infection）与未感染仓鼠肺部的差异调控生物学功能
表S2：感染后16天与未感染仓鼠肺部的差异调控生物学功能
表S3：感染后4天，免疫抑制型新型冠状病毒（SARS-CoV-2）感染仓鼠肺部的差异调控生物学功能
表S4：感染后16天，免疫抑制型新型冠状病毒（SARS-CoV-2）感染仓鼠肺部的差异调控生物学功能
表S5：本研究中用于仓鼠及新型冠状病毒（SARS-CoV-2）基因检测的引物列表