The Silver-Promoted Phosphonation/Alkynylation of Alkene Proceeding with Radical 1,2-Alkynyl Migration

The silver-promoted phosphonation/alkynylation of vinyl in α-aryl α-alkynyl allylic alcohols with phosphine oxide was developed, affording a series of α-alkynyl γ-ketophosphine oxides in moderate to good yields. This procedure involved the radical 3-exo-dig cyclization, proceeding with the radical 1,2-alkynyl migration rather than the aryl migration.

本研究开发了银促进的α-芳基-α-炔基烯丙醇乙烯基位点的膦酰化/炔基化反应，以氧化膦（phosphine oxide）为反应试剂，以中等至良好的收率得到一系列α-炔基γ-酮膦氧化物（α-alkynyl γ-ketophosphine oxides）。该反应过程涉及自由基3-exo-dig环化（radical 3-exo-dig cyclization）步骤，且反应经由自由基1,2-炔基迁移而非芳基迁移的路径进行。