Data_Sheet_2_The experience of buprenorphine implant in patients with opioid use disorder: a series of narrative interviews.docx

BackgroundThis study used narrative medicine (NM) to assess the point of view of patients with opioid use disorder (OUD) and the impact that addiction and a new treatment approach via buprenorphine implant had on their daily lives as compared with previous oral Opioid Agonist Therapy (OAT). MethodsFive patients with OUD undergoing treatment with a buprenorphine subcutaneous implant participated voluntarily and provided their anonymity by self-describing, in response to questions prompted by the clinician, their experience with this innovative therapy. The narratives were analyzed according to standard NM methodology. Citations of patients' positive or negative experiences with traditional OAT and buprenorphine implant were classified according to five categories—patient's determination toward complete opioid abstinence, emotional impact, impact on life, smoothness of therapy, and therapy dependency—and quantified to obtain a picture of the overall therapy experience. ResultsThe analysis revealed the extent of the burden not only of addiction but also of the traditional OAT on patients' life, including relationships with family, job management, and free time. Conversely, the therapy with buprenorphine implant revealed a significant improvement in the quality of life of the patients, who also largely reported a positive emotional outcome during this therapy, as well as a solid determination to achieve complete recovery. ConclusionsThis study illustrates the complex problems of living with OUD and provides insights into the added value of an innovative buprenorphine implant therapy that, due to its administration route and prolonged duration, allows patients to take an additional step toward total opioid abstinence and complete recovery of daily life.### 背景 本研究采用叙事医学（Narrative Medicine, NM），评估阿片类使用障碍（Opioid Use Disorder, OUD）患者的视角，并对比既往口服阿片类激动剂治疗（Opioid Agonist Therapy, OAT），分析成瘾及丁丙诺啡植入剂（buprenorphine implant）这一新型治疗方案对患者日常生活的影响。 ### 方法 本研究纳入5名接受皮下丁丙诺啡植入剂治疗的阿片类使用障碍患者，所有受试者均自愿参与，通过临床医师引导提问、自行叙述的方式匿名分享其接受该创新疗法的诊疗经历。本研究采用标准叙事医学研究方法对上述叙事文本进行分析。将患者提及的传统阿片类激动剂治疗与丁丙诺啡植入剂治疗的正负性体验，按照五大类别进行分类：患者对完全阿片类戒断的决心、情绪影响、生活影响、治疗平顺性及治疗依赖性，并进行量化统计以全面呈现患者的整体治疗体验。 ### 结果 分析结果显示，成瘾与传统阿片类激动剂治疗均给患者生活带来了沉重负担，这一负担涉及家庭关系、工作打理与闲暇时间安排等多个维度。与之相反，丁丙诺啡植入剂治疗可显著改善患者的生活质量，多数受试者报告该治疗期间获得了积极的情绪体验，同时展现出实现完全康复的坚定决心。 ### 结论 本研究阐明了阿片类使用障碍患者的复杂生存困境，并揭示了新型丁丙诺啡植入剂治疗的附加价值：该疗法凭借其给药方式与长效特性，可帮助患者进一步迈向完全阿片类戒断与日常生活的全面康复。