Generating tools for the molecular epidemiology of Campylobacter coli by next generation genome sequencing. Genomics of Campylobacter coli

Aims: 1) TO DETERMINE THE GENOME SEQUENCE OF CAMPYLOBACTER COLI ISOLATES FROM DIFFERENT SOURCES: animal, food, water and environmental, and clinical laboratories. 2) TO DEFINE THE GENETIC VARIATION WITHIN THE CORE AND ACCESSORY REGIONS OF THE GENOME AS DEFINED BY THE SELECTED SERIES OF CAMPYLOBACTER COLI ISOLATES AND BY COMPARISON WITH C. JEJUNI DATA. 3) TO COMPARE THE NEWLY GENERATED CAMPYLOBACTER COLI GENOMIC INFORMATION WITH EXISTING TYPING METHODS 4) TO SUPPORT DEVELOPMENT OF A TYPING SCHEME SPECIFIC FOR CAMPYLOBACTER COLI USING THE INFORMATION OBTAINED FROM THE GENOMES

研究目标如下：1. 解析来自动物、食品、水源、环境及临床实验室等不同来源的结肠弯曲杆菌（Campylobacter coli）分离株的基因组序列；2. 基于所选的一系列结肠弯曲杆菌分离株，并与空肠弯曲杆菌（Campylobacter jejuni，简称C. jejuni）的相关数据进行比对，明确该类菌株基因组核心区域与附属区域内的遗传变异情况；3. 将新生成的结肠弯曲杆菌基因组信息与现有分型方法开展对比分析；4. 依托本研究获得的基因组数据，研发针对结肠弯曲杆菌的特异性分型方案。