Table_2_Exome Sequencing of Native Populations From the Amazon Reveals Patterns on the Peopling of South America.XLSX

Studies on the peopling of South America have been limited by the paucity of sequence data from Native Americans, especially from the east part of the Amazon region. Here, we investigate the whole exome variation from 58 Native American individuals (eight different populations) from the Amazon region and draw insights into the peopling of South America. By using the sequence data generated here together with data from the public domain, we confirmed a strong genetic distinction between Andean and Amazonian populations. By testing distinct demographic models, our analysis supports a scenario of South America occupation that involves migrations along the Pacific and Atlantic coasts. Occupation of the southeast part of South America would involve migrations from the north, rather than from the west of the continent.

针对南美原住民拓殖历史的研究长期受限于美洲原住民基因组序列数据的匮乏，其中亚马逊东部地区的相关数据尤为稀缺。本研究对来自亚马逊地区的58名美洲原住民个体（隶属于8个不同族群）的全外显子组变异情况展开分析，以期为南美定居史研究提供新的见解。我们将本次实验生成的序列数据与公共领域公开数据集相结合，证实安第斯人群与亚马逊人群之间存在显著的遗传分化。通过对多种不同的群体人口模型进行检验，本研究的分析结果支持南美大陆的拓殖模式涉及沿太平洋与大西洋沿岸迁徙的假说：南美东南部地区的人群定居应源自北部的迁徙活动，而非来自该大陆西部的迁徙。