Differentially Expressed Genes for Atrial Fibrillation Identified using RNA Sequencing from Paired Human Left and Right Atrial Appendages.

Next Generation RNA Sequencing was carried out on human paired left and right atrial appendages from patients with and without Atrial Fibrillation. EdgeR software was used to show a total of 247 genes were found to have significant differential expression between left and right atria. Overall design: Left and Right atrial appendages from 5 patients in Sinus Rhythm and 5 patients in atrial fibrillation were subjected to RNA sequencing and differential gene expression using EdgeR.本研究对伴与不伴心房颤动（Atrial Fibrillation）患者的配对人左右心耳组织开展了下一代RNA测序（Next Generation RNA Sequencing）。通过EdgeR软件分析，最终共鉴定出247个在左右心房间存在显著差异表达的基因。 整体实验设计：采集5名窦性心律（Sinus Rhythm）患者与5名心房颤动患者的左右心耳组织，进行RNA测序，并采用EdgeR开展差异基因表达分析。