Table1_Fibromyalgia in obstructive sleep apnea-hypopnea syndrome: a systematic review and meta-analysis.DOCX

Introduction: Fibromyalgia (FM) is a common condition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). This meta-analysis aimed to evaluate differences in sleep monitoring indicators between patients with OSAHS and positive FM and patients with OSAHS and negative FM and to determine the incidence of FM in patients with OSAHS.
Methods: An exhaustive literature review was conducted to analyze the incidence of FM in patients with OSAHS, using online databases, including PubMed, EMBASE, Web of Science, CNKI, and Wanfang, both in English and Chinese. The quality of the included studies was assessed by two researchers using the Newcastle−Ottawa Scale scores. The acquired data were analyzed using Stata 11.0 software. Continuous variables were combined and analyzed using the weighted mean difference as the effect size. Conjoint analyses were performed using random-effects (I2 > 50%) or fixed-effect (I2 ≤ 50%) models based on I2 values.
Results: Fourteen studies met the inclusion criteria. This study showed that 21% of patients with OSAHS experienced FM. Subgroup analyses were performed based on race, age, sex, body mass index, and diagnostic criteria for patients with OSAHS. These findings indicate that obese patients with OSAHS have a higher risk of FM, similar to females with OSAHS. Regarding most sleep monitoring indicators, there were no discernible differences between patients with OSAHS with positive FM and those with negative FM. However, patients with positive FM had marginally lower minimum arterial oxygen saturation levels than those with negative FM. The current literature suggests that patients with OSAHS have a high incidence of FM (21%), and FM has little effect on polysomnographic indicators of OSAHS.
Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024510786, identifier CRD42024510786

引言：纤维肌痛（Fibromyalgia, FM）是阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea-hypopnea syndrome, OSAHS）患者的常见共病。本项荟萃分析旨在对比合并FM的OSAHS患者与未合并FM的OSAHS患者的睡眠监测指标差异，并明确OSAHS患者中FM的发生率。
方法：本研究通过全面的文献检索，分析OSAHS患者中FM的发生率，检索数据库涵盖PubMed、EMBASE、Web of Science、中国知网（CNKI）及万方数据等中英文在线平台。由两名研究者采用纽卡斯尔-渥太华量表（Newcastle−Ottawa Scale）对纳入研究的质量进行评价。采用Stata 11.0软件对获取的数据开展统计分析：连续型变量以加权均数差作为效应量进行合并分析；根据I²值选择效应模型，当I²>50%时采用随机效应模型，当I²≤50%时采用固定效应模型进行合并分析。
结果：最终共有14项研究符合纳入标准。本研究结果显示，21%的OSAHS患者合并FM。基于种族、年龄、性别、体质量指数及OSAHS诊断标准开展亚组分析，结果提示肥胖OSAHS患者与女性OSAHS患者的FM发病风险均更高。在多数睡眠监测指标方面，合并FM与未合并FM的OSAHS患者无明显差异，但合并FM患者的最低动脉血氧饱和度水平略低于未合并FM患者。现有研究表明，OSAHS患者的FM发生率较高（21%），且FM对OSAHS的多导睡眠监测指标影响微弱。
系统评价注册信息：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024510786，注册号为CRD42024510786