Random subnetworks in network proximity to HCV targets are more enriched in differentially expressed genes than random subnetworks.

p-values were calculated using two-sample Kolmogorov-Smirnov (KS) and two sample Wilcoxon-Mann-Whitney (WMW) tests between the enrichment values (f2) for differential expression of 1,000 HRND and 1,000 RND subnetworks.Random subnetworks in network proximity to HCV targets are more enriched in differentially expressed genes than random subnetworks.

本研究采用两样本柯尔莫哥洛夫-斯米尔诺夫（Kolmogorov-Smirnov, KS）检验与两样本威尔科克森-曼-惠特尼（Wilcoxon-Mann-Whitney, WMW）检验，针对1000个HRND子网与1000个RND子网的差异表达富集值（f2）计算得到P值。相较于普通随机子网，与丙型肝炎病毒（Hepatitis C Virus, HCV）靶点具有网络邻近性的随机子网在差异表达基因中的富集程度更高。