Genome-scale mutational signatures of aflatoxin in cells, mice and human tumor

Aflatoxin B1 (AFB1) is a mutagen and IARC Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here we present the first whole genome data on the mutational signatures of AFB1 exposure from a total of > 40,000 mutations in four experimental systems: two different human cell lines, and in liver tumors in wild-type mice and in mice that carried a hepatitis B surface antigen transgene – this to model the multiplicative effects of aflatoxin exposure and hepatitis B in causing HCC.

黄曲霉毒素B1（Aflatoxin B1，AFB1）是一种诱变剂，同时属于国际癌症研究机构（International Agency for Research on Cancer，IARC）划定的1类致癌物，可诱发肝细胞癌（hepatocellular carcinoma，HCC）。本研究首次报道了黄曲霉毒素B1暴露相关突变特征（mutational signatures）的全基因组数据，该数据集来自4种实验体系中共计超过40000个突变：2种不同的人类细胞系，以及野生型小鼠和携带乙型肝炎表面抗原转基因的小鼠的肝脏肿瘤——该实验设计旨在模拟黄曲霉毒素暴露与乙型肝炎共同诱发肝细胞癌的相乘效应。