Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy.

Purpose: Characterization of mechanism and vulnerability of BET protein dependency in GBM cells.Methods: Whole Exome Sequencing of U87/U251 Parental and Resistant cell lines were performed to detect SNVs and copy number alterations in resistant cells.

研究目的：阐明胶质母细胞瘤（Glioblastoma, GBM）细胞中BET蛋白依赖性的分子机制与治疗脆弱性。方法：对U87、U251亲本及耐药细胞系开展全外显子组测序（Whole Exome Sequencing, WES），以检测耐药细胞中的单核苷酸变异（Single Nucleotide Variants, SNVs）与拷贝数改变（Copy Number Alterations, CNAs）。