INFLUENCE OF URIC ACID ON RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ACTIVITY IN CHRONIC KIDNEY DISEASE

Hyperuricemia plays a significant role in the progression of chronic kidney disease by modulating the activity of the renin-angiotensin-aldosterone system. Elevated uric acid levels promote oxidative stress, endothelial dysfunction, and inflammation, which contribute to increased renin, angiotensin II, and aldosterone production. These hormonal changes lead to vasoconstriction, sodium and water retention, hypertension, and renal fibrosis, accelerating kidney injury. Clinical and experimental evidence suggests that early management of hyperuricemia, combined with interventions targeting the renin-angiotensin-aldosterone system, can slow disease progression, reduce proteinuria, and improve patient outcomes. Understanding the interplay between uric acid and hormonal regulation is essential for developing effective therapeutic strategies in patients with chronic kidney disease.