The InsP7 phosphatase Siw14 regulates levels of inositol pyrophosphates and affects activity of general stress transcription factors Msn2 and Msn4

Cells missing the InsP7 phosphatase Siw14 were exposed to osmotic and oxidative stress and the transcriptional response compared to that in a wild-type strain. The data show that the Siw14 delete strain has an elevated stress reponse in log growth conditions, but still mounts a robust response to acute stress. The study includes 5 experiments that measure the impact that the InsP7 phosphatase Siw14 has on the Environmental Stress Response (ESR) in budding yeast

将缺失InsP7磷酸酶（InsP7 phosphatase）Siw14的细胞置于渗透压胁迫与氧化胁迫环境中，并将其转录应答与野生型菌株的转录应答进行对比。实验数据表明，Siw14基因缺失菌株在对数生长期培养条件下的胁迫应答本底水平升高，但仍可对急性胁迫产生强烈的应答反应。本研究共包含5组实验，用于探究InsP7磷酸酶Siw14对出芽酵母环境胁迫应答（Environmental Stress Response, ESR）的影响。