Time course of adriamycin-induced renal dysfunction.

Adriamycin (10 mg/kg) was injected in the tail vein of Balb/c mice. The following parameters were evaluated at days 7, 14 and 21 after ADR injection: mean body weight (g), systolic blood pressure (mmHg), albumin/creatinine ratio, serum albumin (g/dL), urinary and serum creatinine (mg/dl). Results are mean ± SEM of 6–10 mice per group. (*) for P

以10 mg/kg的剂量向Balb/c小鼠尾静脉注射阿霉素(Adriamycin)。分别于阿霉素注射后第7、14、21天，对以下参数进行评估：平均体重（g）、收缩压（mmHg）、白蛋白/肌酐比值、血清白蛋白（g/dL）、尿液与血清肌酐（mg/dL）。实验结果以每组6~10只小鼠的平均值±标准误(SEM)表示。(*)对应P值。