Supplementary Material for: Food insecurity in hidradenitis suppurativa: a cross-sectional analysis from the population-based All of Us Research Program

Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease associated with obesity and low socioeconomic status that can have a significant impact on quality of life. Food insecurity (FI) is associated with a higher likelihood of having a chronic health condition. This cross-sectional study was undertaken to assess the association between HS and FI. Methods We performed secondary analysis of a cross-sectional survey of individuals 18 years and older registered in the National Institutes of Health’s All of Us Research Program in May 2024. The study sample was limited to those who had completed the Children’s HealthWatch Hunger Vital SignTM FI screening survey, validated for use in adults in 2017. HS status was assessed among study participants based on ICD-9/10 diagnosis code (705.83 or L73.2). Multivariable logistic regression was used to characterize the association between HS diagnosis and food security status, adjusting for sex, race and ethnicity, age, and income. Results Among participants with HS, 37/134 (27.6%) screened positive for FI. In comparison, among those without HS, 6,278/56,967 (11%) screened positive. In an adjusted multivariable logistic regression, HS was associated with significantly higher odds of FI (OR: 1.70, 95% CI: 1.09-2.60). Conclusion Study results demonstrated a significant association between HS and FI. Further research is needed to understand specific factors mediating the relationship between HS and FI. The study highlights an opportunity for dermatologists to take an active role in screening for FI in patients with HS and in providing resources as necessary.

引言

化脓性汗腺炎（Hidradenitis suppurativa, HS）是一种慢性炎症性皮肤病，与肥胖及社会经济地位低下相关，可对患者生活质量造成显著负面影响。食物不安全（Food insecurity, FI）与慢性健康疾病的罹患风险升高存在关联。本横断面研究旨在评估HS与FI之间的关联。

方法

我们对2024年5月美国国立卫生研究院（National Institutes of Health, NIH）“我们所有人”研究计划（All of Us Research Program）中注册的18岁及以上个体开展的横断面调查进行了二次分析。研究样本限定为完成《儿童健康观察饥饿生命体征™》（Children’s HealthWatch Hunger Vital SignTM）FI筛查问卷的受试者，该问卷于2017年通过成人使用场景的有效性验证。研究人员依据ICD-9/10诊断编码（705.83或L73.2）评估受试者的HS患病状态。采用多变量logistic回归分析HS诊断与食物安全状况之间的关联，并校正了性别、种族与族裔、年龄及收入等混杂因素。

结果

在HS患者中，有37/134（27.6%）的FI筛查结果呈阳性。相比之下，未患HS的受试者中，6,278/56,967（11%）的FI筛查结果呈阳性。经校正的多变量logistic回归分析显示，HS与FI的患病风险显著升高相关（优势比OR：1.70，95%置信区间CI：1.09-2.60）。

结论

本研究结果证实，HS与FI之间存在显著关联。未来仍需开展进一步研究，以明确介导二者关联的具体因素。本研究同时指出，皮肤科医生可借此契机主动为HS患者开展FI筛查，并在必要时提供相关资源支持。