Data_Sheet_1_Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics.docx

BackgroundToxicity concerns persist in the fields of public health, environmental science, and pharmacology. The intricate and vital role of the gastrointestinal microbiome in influencing toxicity and overall human health has gained increasing recognition in recent years. This study presents a comprehensive bibliometric analysis to evaluate the global scientific output, emerging trends, and research focal points in the area of gastrointestinal microbiome and toxicity.
MethodsThe Web of Science Core Collection database was retrieved for publications on the gastrointestinal microbiome and toxicity from 1980 to 2022. Our analysis included scholarly research papers written in English and excluded duplicate publications. We used Biblioshiny and R to summarize the count and citation metrics of included articles, and visualized research trends and keywords. CiteSpace was used to identify reference literature, keywords, and citation bursts. VOSviewer was used to visualize the network of related countries, institutions, authors, co-cited authors, and keywords.
ResultsA total of 2,140 articles were included, allowing us to identify significant countries, institutions, authors, and research focal points. Our results indicate a growing trend in the field, with China and the United States leading the research. The most productive journal in this area is Science of the Total Environment. Key findings revealed that research hotspots have shifted from drugs to environmental pollutants, emphasizing microplastics. Important mechanisms studied include oxidative stress, metabolism, inflammation, and apoptosis, with target organs being the gastrointestinal tract, liver, and brain. Furthermore, we highlight the rising significance of the gut-brain axis and the usage of zebrafish as a model organism.
ConclusionDespite certain limitations, such as focusing solely on English-language publications and excluding unpublished literature, our findings provide valuable insights into the current state of research on toxicity and the gastrointestinal microbiome. In the future, modifications to the gastrointestinal microbiome could offer new directions for treating and mitigating toxicity. These discoveries provide a comprehensive perspective on the broader scope of this research field.

研究背景：毒性相关问题始终存在于公共卫生、环境科学与药理学领域。近年来，胃肠道微生物组（gastrointestinal microbiome）在调控毒性反应与维持人类整体健康中所发挥的复杂且关键的作用，愈发受到学界的广泛认可。本研究开展了一项全面的文献计量分析，旨在评估胃肠道微生物组与毒性领域的全球科学产出、新兴趋势及研究热点。
研究方法：本研究检索了1980年至2022年间Web of Science核心合集（Web of Science Core Collection）数据库中有关胃肠道微生物组与毒性的文献。本次分析纳入英文发表的学术研究论文，并排除重复发表的成果。研究采用Biblioshiny与R语言对纳入文献的发文量及被引指标进行汇总统计，同时对研究趋势与关键词进行可视化呈现；使用CiteSpace识别参考文献、关键词及引用突现特征；借助VOSviewer可视化展示相关国家、机构、作者、共同被引作者及关键词的共现网络。
研究结果：本次分析共纳入2140篇文献，据此明确了该领域的核心研究国家、机构、作者及研究热点。结果显示，该领域的研究呈持续增长态势，中国与美国在该领域的研究处于领先地位。该领域发文量最高的期刊为《Science of the Total Environment》。关键研究发现表明，研究热点已从药物领域转向环境污染物方向，其中微塑料成为重点研究对象。当前研究的核心机制涵盖氧化应激、代谢、炎症与细胞凋亡，研究靶器官包括胃肠道、肝脏与大脑。此外，本研究还凸显了肠-脑轴（gut-brain axis）的重要性日益提升，以及斑马鱼作为模式生物的应用愈发广泛。
研究结论：尽管本研究存在一定局限性，例如仅纳入英文发表文献且排除了未发表文献，但其研究结果为毒性与胃肠道微生物组领域的当前研究现状提供了极具价值的学术见解。未来，调控胃肠道微生物组有望为毒性的治疗与缓解提供全新的研究方向。本研究的发现为该研究领域的整体范畴提供了全面的学术视角。