The BA.1-NTD reduces the neutralization of BNT162b2 vaccine sera.

Pseudovirus neutralization assays using chimeric spike bearing pseudovirus involving domain swaps between BA.1 spike and Wuhan (D614G) spike against vaccine sera. Shown are the median fold differences in NT50 between the parent spikes and the chimeric spikes. Green shaded represents a decrease in neutralization, red shaded represents increased neutralization. (XLSX)

本数据集包含针对疫苗免疫血清的假病毒中和试验数据，所用假病毒携带嵌合刺突蛋白，该嵌合刺突蛋白通过在BA.1株刺突蛋白与武汉株（D614G突变）刺突蛋白之间进行结构域交换构建而成。数据展示了亲本刺突蛋白与嵌合刺突蛋白的半数中性抑制滴度（NT50）中位倍数差异：绿色阴影区域代表中和活性下降，红色阴影区域代表中和活性升高。(XLSX)