Human lung adenocarcinoma DNA copy number profiling

Lung adenocarcinoma’s genomic alterations exhibit vast variation. Lung adenocarcinoma also has previously described intrinsic gene expression subtypes (Hayes et al. 2006, PMID: 17075127). This study’s aim was to detect and validate subtype-specific alterations. A portion of these specimens were also assayed for genomewide transcription in GSE26939. 103 tumor samples and 30 normal samples were quantified for DNA copy number using Affymetrix SNP microarrays.

肺腺癌（Lung adenocarcinoma）的基因组变异存在广泛的异质性。该肿瘤还存在此前已被报道的固有基因表达亚型（Hayes等，2006年，PMID: 17075127）。本研究旨在检测并验证亚型特异性的基因组变异。其中部分标本还在GSE26939数据集中开展了全基因组转录组检测。本研究使用Affymetrix SNP芯片对103份肿瘤样本与30份正常样本的DNA拷贝数进行了定量分析。