Type 1 cardiorenal syndrome in a patient with an acute infection caused by Trypanosoma cruzi in the Brazilian Amazon region - a case report

Abstract Cardiorenal syndrome type 1 (CRS 1) occurs when acute heart failure leads to acute kidney injury. There are several etiologies of CRS 1, including Chagas disease. Here, we present the first case report of CRS 1 in a patient with acute Chagas disease. Electrocardiography, transthoracic echocardiography, and cardiac magnetic resonance imaging showed signs of acute myocarditis. Laboratory examination revealed severe loss of kidney function, with a creatinine clearance of 30 mL/min, which fully normalized after treatment. Due to emergence of Chagas disease in the Brazilian Amazon, it is important to report unique clinical features in order to improve patients’ outcomes.

摘要：1型心肾综合征（Cardiorenal Syndrome Type 1, CRS 1）指急性心力衰竭诱发急性肾损伤的临床综合征。该类疾病存在多种致病病因，恰加斯病（Chagas Disease）即为其一。本文首次报道了1例急性恰加斯病患者并发1型心肾综合征的病例。心电图检查（Electrocardiography）、经胸超声心动图（Transthoracic Echocardiography）及心脏磁共振成像（Cardiac Magnetic Resonance Imaging）结果均提示存在急性心肌炎征象。实验室检查显示患者肾功能严重受损，肌酐清除率仅为30 mL/min，经治疗后肾功能完全恢复正常。鉴于恰加斯病在巴西亚马逊地区的流行态势，报道此类特殊临床特征对于改善患者预后具有重要意义。