Study 2 data.

Within mindfulness-based programs (MBPs), mixed results have been found for the role of childhood trauma as a moderator of depression outcomes. Furthermore, childhood trauma and PTSD symptoms have been identified as possible risk factors for the occurrence of meditation-related adverse effects (MRAE). The present research examined multiple forms of childhood trauma and PTSD symptoms as predictors of depression treatment outcomes and MRAEs. Various forms of childhood trauma (e.g., abuse and neglect) were examined as predictors of depression treatment outcomes and participant attrition using secondary analyses of two MBP clinical trials (N = 52 and 104, respectively). Study 2 also examined meditation-related side effects (MRSE) and MRAE as outcomes and current subclinical and past PTSD symptoms as predictors. Childhood trauma led to worse depression outcomes across both study 1 and study 2, such that total childhood trauma and childhood sexual abuse were significant predictors across both studies. Childhood sexual abuse predicted attrition in study 2. Finally, multiple forms of childhood trauma and PTSD symptoms predicted MRSE, while total childhood trauma, childhood emotional abuse, and subclinical PTSD symptoms predicted lasting MRAE. Childhood trauma and PTSD symptoms may lead to worse outcomes and a greater occurrence of adverse effects within MBPs for active depression. These results call for further trauma-sensitive modifications, safety monitoring, participant screening, and provider education when implementing these programs.

在基于正念的项目（Mindfulness-Based Programs, MBPs）中，学界针对童年创伤作为抑郁结局调节变量的作用已得出混杂性研究结果。此外，童年创伤与创伤后应激障碍（Post-Traumatic Stress Disorder, PTSD）症状已被证实为冥想相关不良反应（Meditation-Related Adverse Effects, MRAE）发生的潜在风险因素。本研究以多种形式的童年创伤及PTSD症状作为抑郁治疗结局与MRAE的预测变量展开分析。本研究通过对两项MBP临床试验（样本量分别为52例与104例）的二次数据分析，探究了多种形式的童年创伤（如虐待与忽视）作为抑郁治疗结局与受试者脱落率的预测变量的效应。研究2同时以冥想相关副作用（Meditation-Related Side Effects, MRSE）与MRAE作为结局变量，并以当前亚临床状态及既往PTSD症状作为预测变量展开分析。在两项研究中，童年创伤均会导致更差的抑郁结局：总体童年创伤与童年性虐待在两项研究中均为显著的预测变量。童年性虐待可预测研究2中的受试者脱落情况。最终，多种形式的童年创伤与PTSD症状可预测MRSE的发生；而总体童年创伤、童年情感虐待及亚临床PTSD症状则可预测持续性MRAE。对于处于活动性抑郁状态的人群，童年创伤与PTSD症状可能会导致更差的干预结局及更高的不良反应发生率。本研究结果提示，在开展此类项目时，需进一步开展创伤敏感型调整、安全性监测、受试者筛查及从业者教育培训工作。