Sequential Deprotonation–Alkylation of Binaphthyloxy-Substituted Phosphonochalcogenoates: Chiral Tri- and Tetrasubstituted Carbon Centers Adjacent to a Phosphorus Atom

Sequential
deprotonation and alkylation of 1,1′-binaphthyloxy-substituted
phosphonoselenoates and phosphonates resulted in the diastereoselective
formation of chiral tri- and tetrasubstituted carbon centers adjacent
to a phosphorus atom.

以1,1'-联萘氧基取代的硒代膦酸酯（phosphonoselenoates）与膦酸酯（phosphonates）为底物，经连续脱质子与烷基化反应，可非对映选择性构建紧邻磷原子的手性三取代及四取代碳中心。