Data from: Biocidal and Antifouling Chlorinated Protein Films

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Bacteria attach to the surfaces of medical devices and implants, resulting in life-threatening infections. Nonfouling coatings can be used to prevent adhesion of bacteria on the surface, while biocidal coatings kill the microbes. Combining nonfouling and biocidal properties can yield highly effective antimicrobial coatings. We demonstrate here a nanoimprint lithography (NIL)-based method to generate antibacterial coatings that both resist bacterial attachment and kill bacteria. In this strategy nanoimprint lithography was used to create water-stable films of bovine serum albumin (BSA) that are nonadhesive toward bacteria because of their negative/zwitterionic surface potential. Biocidal activity was then imparted through chlorination of cysteine sulfurs, providing slow release of chlorine and potent antimicrobial activity against pathogenic bacteria.

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细菌附着于医疗设备及植入物表面，会引发危及生命的感染。防污涂层可用于阻止细菌在表面附着，而杀菌涂层则能杀灭微生物。将防污与杀菌特性相结合，可获得高效的抗菌涂层。本文展示了一种基于纳米压印光刻（nanoimprint lithography, NIL）的方法，用于制备兼具抗细菌附着与杀菌功能的抗菌涂层。该策略中，纳米压印光刻被用于制备牛血清白蛋白（bovine serum albumin, BSA）的水稳定薄膜，其因表面呈负电位/两性离子电位而具有抗细菌附着性。随后，通过半胱氨酸硫原子的氯化作用赋予其杀菌活性，实现氯的缓慢释放，并对致病菌展现出强效抗菌活性。