Simultaneous Infection with Enterobacteriaceae and Pseudomonas aeruginosa harboring Multiple Carbapenemases in a Returning Traveler colonized with Candida auris. Multi-Drug Resistant Gram-Negative Pathogens with One Short-Read C. auris Assembly

Submission of consensus genome assemblies from a critically ill patient with polymicrobial infections due to multi-drug resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa who had traveled to India and was also colonized by Candida auris. A precision medicine approach using whole genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181. This case illustrates the rapidly evolving landscape of resistance and its challenges to clinicians.

本数据集收录了一名重症患者的共识基因组组装提交数据，该患者因多重耐药大肠埃希菌（Escherichia coli）、肺炎克雷伯菌（Klebsiella pneumoniae）与铜绿假单胞菌（Pseudomonas aeruginosa）引发复数菌感染，曾赴印度旅行，且同时定植有耳念珠菌（Candida auris）。研究采用全基因组测序的精准医学策略，揭示了其体内携带的多种与NDM-1、NDM-5及OXA-181相关的移动遗传元件。该案例展现了耐药性领域快速演变的态势，及其给临床医师带来的诸多挑战。