Effects of okadaic acid exposure on gut bacterial diversity in rats

Okadaic acid (OA) is a widely distributed marine biotoxin with cytotoxic, genotoxic, tumor-promoting, and even carcinogenic properties. The increased foodborne poisoning risk of OA due to marine pollution made it more unignorable. However, the toxic mechanism is not clear yet in vivo. The interaction between OA and bacteria suggest that gut bacteria have a potential role in the toxicity of OA, which may be one of the reasons for the complex toxicity of OA, but it needs to be confirmed. This project is dedicated to studying differences in diversity of gut bacteria in rats after OA exposure.

冈田酸（Okadaic acid, OA）是一种广泛分布的海洋生物毒素，兼具细胞毒性、基因毒性、促瘤活性与致癌性。海洋污染使得OA引发食源性中毒的风险攀升，使其愈发不容忽视。然而，其体内毒性机制尚未阐明。OA与细菌的相互作用提示，肠道菌群可能在OA的毒性效应中发挥潜在作用，这或为OA毒性复杂化的成因之一，但仍有待进一步验证。本研究旨在探究OA暴露后大鼠肠道菌群多样性的差异特征。